A COMPARATIVE ANALYSIS OF DEMINERALISED FREEZE-DRIED BONE (DFDBA), FRESH FROZEN BONE ALLOGRAFT (FFBA) AND AUTOGENOUS BONE GRAFT (AU)—A HISTOLOGIC STUDY IN RABBITS
by Daniel Isaac Sendyk (Brazil), Julio Leonardo de Oliveira Lima, Cristiane Ibanhes Polo, Wilson Roberto Sendyk, Maria da Graça Naclério-Homem, Maria Cristina Zindel Deboni

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Classification: Tools/Materials, Regenerative materials, Research, Research Type, Pre-clinical, Regeneration, Events, Symposia / Congresses
Content
Objectives: There are different clinical applications for bone grafts in alveolar reconstructions and difficulties in achieving vertical osseous increase. This study was to make a comparative histological evaluation of DFDBA, FFBA, AU and blood clot (CO) on vertical guided bone regeneration (GBR) in rabbit calvaria.
Methods: Nine rabbits were used. One was the primary bone graft donor and eight were GBR models, whereby 32 titanium cylinders were fixed to the calvaria and randomly filled with DFDBA, FFBA, AU or CO. The animals were killed 13 weeks later and the contents of the cylinders were analysed histomorphologically and histomorphometrically to quantify the total area (AT) of newly formed tissue, new bone (NB) and residual graft (RG) particles.
Results: Mean values of AT were significantly higher for DFDBA and FFBA in the order DFDBA = FFBA > AU > CO. New bone formation with DFDBA and FFBA was better than with AU or CO. There were more RG particles in the DFDBA models, in the order FFBA > DFDBA = AU = CO (p values
Conclusions: Allografts containing DFDBA and FFBA can be considered beneficial for achieving new vertical bone formation.
Details
Osteology Foundation
Content Type:
Poster
Publication date:
07/11/2015
Publisher:
Osteology Foundation