A RANDOMISED CLINICAL TRIAL FOR RIDGE PRESERVATION USING TWO TYPES OF COLLAGENATED XENOGRAFT/COLLAGEN MEMBRANE—A CONE-BEAM CT STUDY
by Hyun-Chang Lim (South Korea), Ui-Won Jung, Hoon You, Seong-Ho Choi, Jung-Seok Lee

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Objectives: This randomised controlled clinical trial aimed to radiographically compare horizontal and vertical alteration of alveolar ridge following extraction-socket grafting with different combinations of biomaterials: collagenated porcine bone and cross-linked collagen membrane (test group) versus collagenated bovine bone and non-cross-linked collagen membrane (control group). Methods: This study included patients who required at least one anterior or premolar extraction, were aged 20 years old or more, and were able to understand the informed consent. Tooth replacement was planned using either conventional or implant-supported fixed partial dentures. Sample size calculations required 13 patients per group to obtain 80% power at a two-sided alpha level of 0.05%. A total of 30 patients were enrolled, and 15 were randomly allocated to each group. All were blinded to their allocations. Following a single tooth extraction, a collagenated bone substitute was used to fill in the socket, and a collagen membrane was used to cover it. Primary flap closure with several flap designs was attempted. Cone-beam CT (CBCT) scanning was carried out to assess the change in alveolar ridge, once immediately after ridge preservation and once after 4 months of healing. The primary outcome was horizontal alteration of alveolar ridge. Secondary outcomes were vertical alteration of alveolar ridge and clinical handling of the bone substitute and barrier membrane. Results: One patient in the control group dropped out and 3 patients did not receive the allocated intervention in the test group. Intention-to-treat (ITT; control group 14, test group 15) and per protocol (PP; control group 14, test group 12) analyses were performed. In the control and test group, 8 and 7 cases, respectively, showed membrane exposure, secondary healing was uneventful in all cases. There was no statistical difference in ITT and PP analysis between the groups in horizontal alteration of alveolar ridge width, but vertical height in the midfacial area was significantly reduced in the test group. The handling properties of the barrier membrane showed no statistically differences, but the handling properties of the bone substitute was significantly superior in the control group. Conclusions: Ridge preservation using collagenated porcine bone/cross-linked collagen membrane showed similar horizontal ridge alteration to collagenated bovine bone/non-cross-linked collagen membrane. However, vertical ridge changes were more pronounced with the collagenated porcine bone/cross-linked collagen membrane. Further studies including histometric evaluation are required.
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Content Type:
Poster
Publication date:
02/12/2015
Publisher: